Cryo-EM structure of apo state human Cav3.2
Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 9ayg
Q-score: 0.537
Huang J, Fan X, Jin X, Lyu C, Guo Q, Liu T, Chen J, Davakan A, Lory P, Yan N
Cell Res (2024) [ DOI: doi:10.1038/s41422-024-00959-8 Pubmed: 38605177 ]
- Voltage-dependent t-type calcium channel subunit alpha-1h (Complex from Homo sapiens)
- Cholesterol hemisuccinate (486 Da, Ligand)
- Calcium ion (40 Da, Ligand)
- Voltage-dependent t-type calcium channel subunit alpha-1h (234 kDa, Protein from Homo sapiens)
- [(2~{r})-3-[2-azanylethoxy(oxidanyl)phosphoryl]oxy-2-pentadecanoyloxy-propyl] pentadecanoate (663 Da, Ligand)
- 1-o-octadecyl-sn-glycero-3-phosphocholine (510 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
Cryo-EM structure of human Cav3.2 with TTA-A2
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 9ayh
Q-score: 0.52
Huang J, Fan X, Jin X, Lyu C, Guo Q, Liu T, Chen J, Davakan A, Lory P, Yan N
Cell Res (2024) [ DOI: doi:10.1038/s41422-024-00959-8 Pubmed: 38605177 ]
- Voltage-dependent t-type calcium channel subunit alpha-1h (Complex from Homo sapiens)
- Cholesterol hemisuccinate (486 Da, Ligand)
- Calcium ion (40 Da, Ligand)
- Voltage-dependent t-type calcium channel subunit alpha-1h (234 kDa, Protein from Homo sapiens)
- [(2~{r})-3-[2-azanylethoxy(oxidanyl)phosphoryl]oxy-2-pentadecanoyloxy-propyl] pentadecanoate (663 Da, Ligand)
- 1-o-octadecyl-sn-glycero-3-phosphocholine (510 Da, Ligand)
- 2-(4-cyclopropylphenyl)-n-{(1r)-1-[5-(2,2,2-trifluoroethoxy)pyridin-2-yl]ethyl}acetamide (378 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
Cryo-EM structure of human Cav3.2 with TTA-P2
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 9ayj
Q-score: 0.484
Huang J, Fan X, Jin X, Lyu C, Guo Q, Liu T, Chen J, Davakan A, Lory P, Yan N
Cell Res (2024) [ DOI: doi:10.1038/s41422-024-00959-8 Pubmed: 38605177 ]
- Voltage-dependent t-type calcium channel subunit alpha-1h (Complex from Homo sapiens)
- Cholesterol hemisuccinate (486 Da, Ligand)
- Calcium ion (40 Da, Ligand)
- Voltage-dependent t-type calcium channel subunit alpha-1h (234 kDa, Protein from Homo sapiens)
- 3,5-dichloro-n-[(1-{[(4s)-2,2-dimethyloxan-4-yl]methyl}-4-fluoropiperidin-4-yl)methyl]benzamide (431 Da, Ligand)
- [(2~{r})-3-[2-azanylethoxy(oxidanyl)phosphoryl]oxy-2-pentadecanoyloxy-propyl] pentadecanoate (663 Da, Ligand)
- 1-o-octadecyl-sn-glycero-3-phosphocholine (510 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
Cryo-EM structure of human Cav3.2 with ML218
Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 9ayk
Q-score: 0.519
Huang J, Fan X, Jin X, Lyu C, Guo Q, Liu T, Chen J, Davakan A, Lory P, Yan N
Cell Res (2024) [ DOI: doi:10.1038/s41422-024-00959-8 Pubmed: 38605177 ]
- Voltage-dependent t-type calcium channel subunit alpha-1h (Complex from Homo sapiens)
- Cholesterol hemisuccinate (486 Da, Ligand)
- Calcium ion (40 Da, Ligand)
- Voltage-dependent t-type calcium channel subunit alpha-1h (234 kDa, Protein from Homo sapiens)
- 3,5-dichloro-n-{[(1r,5s,6r)-3-(3,3-dimethylbutyl)-3-azabicyclo[3.1.0]hexan-6-yl]methyl}benzamide (369 Da, Ligand)
- [(2~{r})-3-[2-azanylethoxy(oxidanyl)phosphoryl]oxy-2-pentadecanoyloxy-propyl] pentadecanoate (663 Da, Ligand)
- 1-o-octadecyl-sn-glycero-3-phosphocholine (510 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
Cryo-EM structure of human Cav3.2 with ACT-709478
Resolution: 2.8 Å
EM Method: Single-particle
Fitted PDBs: 9ayl
Q-score: 0.531
Huang J, Fan X, Jin X, Lyu C, Guo Q, Liu T, Chen J, Davakan A, Lory P, Yan N
Cell Res (2024) [ DOI: doi:10.1038/s41422-024-00959-8 Pubmed: 38605177 ]
- Voltage-dependent t-type calcium channel subunit alpha-1h (Complex from Homo sapiens)
- Cholesterol hemisuccinate (486 Da, Ligand)
- Calcium ion (40 Da, Ligand)
- Voltage-dependent t-type calcium channel subunit alpha-1h (234 kDa, Protein from Homo sapiens)
- [(2~{r})-3-[2-azanylethoxy(oxidanyl)phosphoryl]oxy-2-pentadecanoyloxy-propyl] pentadecanoate (663 Da, Ligand)
- 1-o-octadecyl-sn-glycero-3-phosphocholine (510 Da, Ligand)
- N-{1-[(5-cyanopyridin-2-yl)methyl]-1h-pyrazol-3-yl}-2-{4-[1-(trifluoromethyl)cyclopropyl]phenyl}acetamide (425 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
Inner channel lipids regulated gating mechanism of human pannexins
Resolution: 3.8 Å
EM Method: Single-particle
Fitted PDBs: 8gyo
Q-score: 0.353
To Be Published
- Digitonin (1 kDa, Ligand)
- Pannexin-1 (48 kDa, Protein from Homo sapiens)
- 1,2-diacyl-sn-glycero-3-phosphocholine (790 Da, Ligand)
- Pannexin-1 (350 kDa, Complex from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
Cryo-EM structure of human Pannexin-3 in closed state
Resolution: 3.5 Å
EM Method: Single-particle
Fitted PDBs: 8gyp
Q-score: 0.406
To Be Published
- Pannexin-3 (44 kDa, Protein from Homo sapiens)
- Pannexin-3 (350 kDa, Complex from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
Cryo-EM structure of human Pannexin-2 in pre-open state
Resolution: 3.4 Å
EM Method: Single-particle
Fitted PDBs: 8gyq
Q-score: 0.405
To Be Published
- Pannexin-2 (74 kDa, Protein from Homo sapiens)
- Pannexin-2 (500 kDa, Complex from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
Cryo-EM structure of human Pannexin-3 R36S/F40R variant in pre-open state
Resolution: 3.68 Å
EM Method: Single-particle
Fitted PDBs: 8gyt
Q-score: 0.363
Cong Y, Jin X, Kong F, Wu T, Yan C
To Be Published
- Pannexin-3 r36s/f40r (350 kDa, Complex from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Pannexin-3 (44 kDa, Protein from Homo sapiens)
Voltage-gated sodium channel Nav1.7 variant M9
Resolution: 2.89 Å
EM Method: Single-particle
Fitted PDBs: 8xmm
Q-score: 0.544
Li Z, Wu Q, Huang G, Jin X, Li J, Pan X, Yan N
PNAS (2024) 121 pp. e2322899121-e2322899121 [ Pubmed: 38381792 DOI: doi:10.1073/pnas.2322899121 ]
- Cholesterol (386 Da, Ligand)
- Voltage-gated sodium channel nav1.7-m9 (Complex from Homo sapiens)
- 1,2-dioleoyl-sn-glycero-3-phosphocholine (787 Da, Ligand)
- O-[(r)-{[(2r)-2,3-bis(octadecanoyloxy)propyl]oxy}(hydroxy)phosphoryl]-l-serine (792 Da, Ligand)
- (2s,3r,4e)-2-(acetylamino)-3-hydroxyoctadec-4-en-1-yl dihydrogen phosphate (421 Da, Ligand)
- 1-o-octadecyl-sn-glycero-3-phosphocholine (510 Da, Ligand)
- Sodium channel protein type 9 subunit alpha (231 kDa, Protein from Homo sapiens)
- Sodium channel subunit beta-1 (26 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)